BROCHURES / DOCUMENTATION
APPLICATION NOTES
SCIENTIFIC PUBLICATIONS
You are researching: Poly(styrene) (ethylene/butylene)–(styrene)
Cell Type
Tissue and Organ Biofabrication
Skin Tissue Engineering
Drug Delivery
Biological Molecules
Solid Dosage Drugs
Stem Cells
Personalised Pharmaceuticals
Inducend Pluripotent Stem Cells (IPSCs)
Drug Discovery
Cancer Cell Lines
All Groups
- Biomaterial
- Non-cellularized gels/pastes
- Poly(N-isopropylacrylamide) (PNIPAAm)
- Mineral Oil
- poly(octanediol-co-maleic anhydride-co-citrate) (POMaC)
- Poly(Oxazoline)
- Poly(trimethylene carbonate)
- 2-hydroxyethyl) methacrylate (HEMA)
- Zein
- Acrylamide
- Pluronic – Poloxamer
- Polyisobutylene
- Paraffin
- Silicone
- Konjac Gum
- Polyphenylene Oxide
- Ionic Liquids
- Polyvinylpyrrolidone (PVP)
- Gelatin-Sucrose Matrix
- Salt-based
- Chlorella Microalgae
- Acrylates
- Poly(Vinyl Formal)
- 2-hydroxyethyl-methacrylate (HEMA)
- Phenylacetylene
- Magnetorheological fluid (MR fluid – MRF)
- Salecan
- Poly(vinyl alcohol) (PVA)
- PEDOT
- Jeffamine
- Poly(methyl methacrylate) (PMMA)
- Polyethylene
- SEBS
- Polypropylene Oxide (PPO)
- Carbopol
- Sucrose Acetate
- Epoxy
- poly (ethylene-co -vinyl acetate) (PEVA)
- Poly(itaconate-co-citrate-cooctanediol) (PICO)
- Micro/nano-particles
- Biological Molecules
- Bioinks
- (2-Hydroxypropyl)methacrylamide (HPMA)
- Methacrylated Collagen (CollMA)
- Carrageenan
- Glucosamine
- Chitosan
- Glycerol
- Poly(glycidol)
- Alginate
- Agarose
- Gelatin-Methacryloyl (GelMA)
- methacrylated chondroitin sulfate (CSMA)
- Cellulose
- Novogel
- carboxybetaine acrylamide (CBAA)
- Hyaluronic Acid
- Peptide gel
- Methacrylated Silk Fibroin
- Pantoan Methacrylate
- Polyethylene glycol (PEG) based
- α-Bioink
- Poly(Acrylic Acid)
- Collagen
- Elastin
- Heparin
- sulfobetaine methacrylate (SBMA)
- Gelatin
- Matrigel
- Gellan Gum
- Methacrylated Chitosan
- Methacrylated hyaluronic acid (HAMA)
- Pectin
- Silk Fibroin
- Pyrogallol
- Xanthan Gum
- Fibrinogen
- Fibrin
- Paeoniflorin
- Fibronectin
- Ceramics
- Decellularized Extracellular Matrix (dECM)
- Metals
- Solid Dosage Drugs
- Thermoplastics
- Coaxial Extruder
- Non-cellularized gels/pastes
- Bioprinting Technologies
- Bioprinting Applications
- Cell Type
- Retinal
- Chondrocytes
- Embrionic Kidney (HEK)
- Corneal Stromal Cells
- Annulus Fibrosus Cells
- Fibroblasts
- β cells
- Astrocytes
- Myoblasts
- Pericytes
- Hepatocytes
- Cancer Cell Lines
- Bacteria
- Epicardial Cells
- Articular cartilage progenitor cells (ACPCs)
- Tenocytes
- Extracellular Vesicles
- Osteoblasts
- Monocytes
- Mesothelial cells
- Nucleus Pulposus Cells
- Epithelial
- Neutrophils
- Adipocytes
- Smooth Muscle Cells
- T cells
- Human Umbilical Vein Endothelial Cells (HUVECs)
- Organoids
- Stem Cells
- Spheroids
- Meniscus Cells
- Synoviocytes
- Keratinocytes
- Skeletal Muscle-Derived Cells (SkMDCs)
- Neurons
- Macrophages
- Human Trabecular Meshwork Cells
- Endothelial
- CardioMyocites
- Melanocytes
- Institution
- Chalmers University of Technology
- Karlsruhe institute of technology
- University of Freiburg
- Helmholtz Institute for Pharmaceutical Research Saarland
- Leipzig University
- AO Research Institute (ARI)
- Shanghai University
- Univerity of Hong Kong
- University of Toronto
- Brown University
- Polish Academy of Sciences
- University of Wurzburg
- Technical University of Dresden
- University of Nantes
- Montreal University
- Shandong Medical University
- Institute for Bioengineering of Catalonia (IBEC)
- University of Michigan – School of Dentistry
- Myiongji University
- Harbin Institute of Technology
- Technical University of Berlin
- University of Amsterdam
- University of Tel Aviv
- University of Applied Sciences Northwestern Switzerland
- Anhui Polytechnic
- University Children's Hospital Zurich
- Bayreuth University
- Aschaffenburg University
- University of Michigan, Biointerfaces Institute
- Abu Dhabi University
- Jiao Tong University
- University of Aveiro
- Ghent University
- Chiao Tung University
- Sree Chitra Tirunal Institute
- University of Sheffield
- University of Michigan – Biointerfaces Institute
- National University of Singapore
- CIC biomaGUNE
- Kaohsiung Medical University
- DTU – Technical University of Denmark
- University of Taiwan
- Adolphe Merkle Institute Fribourg
- Halle-Wittenberg University
- Baylor College of Medicine
- INM – Leibniz Institute for New Materials
- National Yang Ming Chiao Tung University
- University of Vilnius
- Zurich University of Applied Sciences (ZHAW)
- Innotere
- L'Oreal
- Tiangong University
- Xi’an Children’s Hospital
- ETH Zurich
- Hallym University
- Nanjing Medical University
- University of Bordeaux
- Innsbruck University
- DWI – Leibniz Institute
- Nanyang Technological University
- National Institutes of Health (NIH)
- Ningbo Institute of Materials Technology and Engineering (NIMTE)
- KU Leuven
- Politecnico di Torino
- Utrecht Medical Center (UMC)
- Rizzoli Orthopaedic Institute
- Queen Mary University
- Veterans Administration Medical Center
- University of Manchester
- University of Bucharest
- Royal Free Hospital
- Hong Kong University
- University of Barcelona
- Chinese Academy of Sciences
- ENEA
- University of Nottingham
- University of Geneva
- SINTEF
- Rice University
- Jiangsu University
- Trinity College
- Novartis
- University of Central Florida
- Hefei University
- Leibniz University Hannover
- Biomaterials & Bioinks
- Application
- Bioelectronics
- Biomaterial Processing
- Tissue Models – Drug Discovery
- Industrial
- Drug Discovery
- In Vitro Models
- Robotics
- Electronics – Robotics – Industrial
- Medical Devices
- Tissue and Organ Biofabrication
- Adipose Tissue Engineering
- Trachea Tissue Engineering
- Ocular Tissue Engineering
- Intervertebral Disc (IVD) Tissue Engineering
- Muscle Tissue Engineering
- Liver tissue Engineering
- Cartilage Tissue Engineering
- Bone Tissue Engineering
- Dental Tissue Engineering
- Drug Delivery
- Urethra Tissue Engineering
- Skin Tissue Engineering
- Uterus Tissue Engineering
- Nerve – Neural Tissue Engineering
- Meniscus Tissue Engineering
- Heart – Cardiac Patches Tissue Engineering
- BioSensors
- Personalised Pharmaceuticals
- Review Paper
- Printing Technology
AUTHOR
Title
Heart-on-a-Chip Model of Epicardial–Myocardial Interaction in Ischemia Reperfusion Injury
[Abstract]
Year
2024
Journal/Proceedings
Advanced Healthcare Materials
Reftype
DOI/URL
DOI
Groups
AbstractAbstract Epicardial cells (EPIs) form the outer layer of the heart and play an important role in development and disease. Current heart-on-a-chip platforms still do not fully mimic the native cardiac environment due to the absence of relevant cell types, such as EPIs. Here, using the Biowire II platform, engineered cardiac tissues with an epicardial outer layer and inner myocardial structure are constructed, and an image analysis approach is developed to track the EPI cell migration in a beating myocardial environment. Functional properties of EPI cardiac tissues improve over two weeks in culture. In conditions mimicking ischemia reperfusion injury (IRI), the EPI cardiac tissues experience less cell death and a lower impact on functional properties. EPI cell coverage is significantly reduced and more diffuse under normoxic conditions compared to the post-IRI conditions. Upon IRI, migration of EPI cells into the cardiac tissue interior is observed, with contributions to alpha smooth muscle actin positive cell population. Altogether, a novel heart-on-a-chip model is designed to incorporate EPIs through a formation process that mimics cardiac development, and this work demonstrates that EPI cardiac tissues respond to injury differently than epicardium-free controls, highlighting the importance of including EPIs in heart-on-a-chip constructs that aim to accurately mimic the cardiac environment.
AUTHOR
Title
Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways
[Abstract]
Year
2024
Journal/Proceedings
Nature Cardiovascular Research
Reftype
Hamidzada2024
DOI/URL
DOI
Groups
AbstractYolk sac macrophages are the first to seed the developing heart; however, owing to a lack of accessible tissue, there is no understanding of their roles in human heart development and function. In this study, we bridge this gap by differentiating human embryonic stem (hES) cells into primitive LYVE1+ macrophages (hESC-macrophages) that stably engraft within contractile cardiac microtissues composed of hESC-cardiomyocytes and fibroblasts. Engraftment induces a human fetal cardiac macrophage gene program enriched in efferocytic pathways. Functionally, hESC-macrophages trigger cardiomyocyte sarcomeric protein maturation, enhance contractile force and improve relaxation kinetics. Mechanistically, hESC-macrophages engage in phosphatidylserine-dependent ingestion of apoptotic cardiomyocyte cargo, which reduces microtissue stress, leading hESC-cardiomyocytes to more closely resemble early human fetal ventricular cardiomyocytes, both transcriptionally and metabolically. Inhibiting hESC-macrophage efferocytosis impairs sarcomeric protein maturation and reduces cardiac microtissue function. Together, macrophage-engineered human cardiac microtissues represent a considerably improved model for human heart development and reveal a major beneficial role for human primitive macrophages in enhancing early cardiac tissue function.
AUTHOR
Title
Flexible 3D printed microwires and 3D microelectrodes for heart-on-a-chip engineering
[Abstract]
Year
2023
Journal/Proceedings
Biofabrication
Reftype
DOI/URL
DOI
Groups
AbstractWe developed a heart-on-a-chip platform that integrates highly flexible, vertical, 3D micropillar electrodes for electrophysiological recording and elastic microwires for the tissue’s contractile force assessment. The high aspect ratio microelectrodes were 3D-printed into the device using a conductive polymer, poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT:PSS). A pair of flexible, quantum dots/thermoplastic elastomer nanocomposite microwires were 3D printed to anchor the tissue and enable continuous contractile force assessment. The 3D microelectrodes and flexible microwires enabled unobstructed human iPSC-based cardiac tissue formation and contraction, suspended above the device surface, under both spontaneous beating and upon pacing with a separate set of integrated carbon electrodes. Recording of extracellular field potentials using the PEDOT:PSS micropillars was demonstrated with and without epinephrine as a model drug, non-invasively, along with in situ monitoring of tissue contractile properties and calcium transients. Uniquely, the platform provides integrated profiling of electrical and contractile tissue properties, which is critical for proper evaluation of complex, mechanically and electrically active tissues, such as the heart muscle under both physiological and pathological conditions.